- Holder of the e-health chair
e-health & digital systems
Campus: Toulon
+ 33 7 86 59 21 65
They didn't know that was impossible, so they did it
Core business
Dominique Collard is an ISEN Lille 1980 graduate.
Now a research director at CNRS, Dominique spent 15 years of his life in Japan over 3 periods.
He first worked for Toshiba in microelectronics and then joined the CNRS in 1988.
The CNRS wanted to create a joint laboratory with the University of Tokyo, and given his background, Dominique was one of the "first in line" for this nugget laboratory of the CNRS.
Back in France for the CNRS, Dominique directs research in Lille and implements technology transfer from Japan in the field of cancer research.
Prospective
One project is particularly close to Dominique's heart, and she puts all her energy into it. It concerns cancer, and more specifically the detection of cancer cells in the blood.
Circulating tumor cells (CTCs) are cells that are ejected from a primary tumor and re-implant themselves in other organs to metastasize.
These cells are so heterogeneous that no common protocol has yet been found. However, when a tumor cell becomes circulating, it acquires physical properties. These cells surround themselves with a certain number of proteins and therefore have a charged membrane.
Our approach: to be able to perform cell sorting, to detect CTCs not on the basis of a biological approach but on the basis of a physicist's approach, via electrical and mechanical measurements.
The device: starting with a blood sample, perform standard treatments and in the remaining cells perform mechanical and physical characterization of suspect cells and determine a profile.
360°
A "Digital Systems and Life Sciences" chair has been created to promote a multi-disciplinary approach (micro-technology, biology and health), to be able to give lectures and carry out collaborations with partners.
In terms of teaching, the courses are at the frontier between micro-electronics technology, biology and health, with health monitoring, bio-cellular analysis sensors and so on.
About me
My career as a researcher has been strongly shaped by the various mobility experiences I've had. I used my last mobility experience to set up an ambitious interdisciplinary project combining bio-MEMS and cancer research. My first post-doctoral stay at the TOSHIBA VLSI research Center (1985-1986), Kawasaki, Japan, in microelectronics, enabled me on my return to promote digital simulation activities for silicon technologies and devices within the IEMN. The second mobility took place at LIMMS/CNRS-IIS, Tokyo, Japan (1995-1997) with a first thematic shift towards microsystems. During this stay, a new 3D self-assembly technology was developed and, thanks to the support of our Japanese partners, transferred to IEMN. This contributed to the establishment of microsystem activities and technologies at IEMN, and to the extension of cleanroom facilities. My third move involved a second thematic shift towards bioMEMS. The spin-offs concern the transfer of these technologies to cancer research in the Lille region as of my return in April 2016 as part of the SMMiL-E project. This initiative has received the support of the Contrat de Plan Etat Région (State-Region Plan Contract) and is at the origin of the Yncréa Chair: Digital System and Life Science. These experiences enabled me to coordinate the CPER ONCO-Lille project, direct the SMMiL-E program, and develop the Yncrea chair towards preclinical studies and valorization towards industrial activities and company creation.
Areas of expertise
- BioMEMS: Exploitation and development of microdevices for cancer applications
- Biophysical cytometry: Characterization and cellular and molecular study.
- Research Director 1 class CNRS LIMMS/CNRS-IIS: UMI 2820
- Holder of the Yncréa Chair in Digital Systems and Life Sciences and Director of the Lille campus
Research and development activities
- RESEARCH PROJECT AND AGREEMENT: SMMiL-E
This project concerns the transfer of LIMMS/CNRS-IIS bioMEMS technologies to France. Building on existing collaborations under the INSERM/physicancer project with IEMN (UMR 8520), the Institut de biologie de Lille (UMR 8161) and the Oscar Lambret Center, the transfer will take place in the Lille region in close collaboration with IEMN. In view of the focus on technological cancer research, the hosting platform has now been set up and is operational at the Centre Oscar Lambret site, within the regional university hospital cluster, so as to be as close as possible to the medical teams. This agreement, SMMIL-E (Seeding Microsystem in Medecine in Lille - European-Japanese Technologies againt Cancer), has become the mirror structure of LIMMS in France, signed on June 16, 2014 by the CNRS, the Institute of Industrial Sciences of the University of Tokyo, the University of Lille 1 and the Oscar Lambret Center. SMMIL-E was selected in the State-Region Plan Contract supported by CNRS, INSERM, Lille Métropole Européenne and the Universities as a key program for structuring cancer research in Lille.
In SMMiL-E, beyond management, my research program entitled ONCO-MEMS -Micro Electro Mechanical Systems and methods for clinical research in Oncology- aims to push forward and propose bio-physical characterization (mechanical, electrical, electromechanical) as an alternative to molecular, cellular and tumor biological tests when biological markers are inoperative. - CONTRAT DE PLAN ETAT-REGION : IRICL: Institut de Recherche Intégré sur le Cancer
2015 - 2020 Coordinator with Yvan de Launoit and Bruno Quesnel
The project aims to create a multidisciplinary cancer research institute of international stature on the Lille University Hospital site, to considerably strengthen the scientific base on which the ONCOLille SIRIC is built, and become a world reference in the exploration of tumor dormancy and resistance to anti-cancer treatments. This Institute, designed to enable daily interactions between biologists, chemists, physicists, doctors and social and human sciences researchers, in close contact with the clinic, will bring together existing cancer research forces, welcome new teams and include innovative platforms, notably in the field of micro technologies with the establishment of a LIMMS-University of Tokyo team.
Links
- Oscar Lambret Center
- CNRS
- Institute of Science of the University of Tokyo
- University of Lille
- LIMMS/CNRS-IIS
- IEMN
- Inserm
- Lille University Hospital
Teaching activities
- 1985 - : 27 thesis directions (6 during the 2012-2018 period)
2 directions for Habilitation to Supervise Research - 1985 - : 27 participations in thesis juries in French universities and Tokyo University
- 1987 - 1995: Lecturer in semiconductor devices at ISEN, Lille (student prize)
- 1998 - 2004: Lectures on MEMS devices at ISEN and the University of Lille
- 2010 - : Courses (partial) on MEMS and BioMEMS devices at the University of Tokyo in Master Electronic Engineering and Precision Engineering
- 2018 - : Course / Conference on microsystems applied to the medical field.
- 2021: International course in the SMMiL-E School: BIOMEMS and Biophysical Cytometry
Publications
I am the author of 90 publications in refereed journals and 200 publications in refereed conference proceedings. If I had to choose 5, here's the one I'd present to you:
- 1) D. Collard and K. Taniguchi, "IMPACT, a point defect based two-dimensional process simulator: modeling of lateral oxidation enhanced diffusion of dopants in silicon," IEEE Trans. Electron Devices, vol. ED-33, pp. 1454-1462, 1986.
- 2) T. Akiyama, D. Collard and H. Fujita "Scratch Drive Actuator with mechanical links for Self-assembly of three-dimensional MEMS", J. Microelectromechanical Syst., Vol. 6, pp. 10-17,1997.
- 3) D. Collard, S. H. Kim, T. Osaki, M. Kumemura, B. Kim, D. Fourmy, T. Fujii, S. Takeuchi, S. L. Karsten, and H. Fujita, "Nano bioresearch approach by microtechnology," Drug discovery today, vol. 18, pp. 552-559, 2013 (invited).
- 4) G. Perret, T. Lacornerie, F. Manca, S. Giordano, M. Kumemura, ... and D. Collard, "Real-time mechanical characterization of DNA degradation under therapeutic X-rays and its theoretical modeling," Nature.com / Microsystems & Nanoengineering, vol. 2, p. 16062, 12/05/online 2016.
- 5) C. M. Tarhan, R. Yokokawa, L. Jalabert, D. Collard, and H. Fujita, "Pick-and-Place Assembly of Single Microtubules," Small, vol. 13, pp. 1701136, 2017 (and cover).
